What is a significant advantage of using the REST API for application development?

The significant advantage of using the REST API for application development lies in its lightweight nature and ease of use. REST APIs operate on standard HTTP methods (such as GET, POST, PUT, DELETE), which makes them straightforward to implement and understand. This simplicity allows developers to quickly get up and running with their applications, fostering rapid development cycles and facilitating integration with various platforms and programming environments.

Additionally, because REST APIs typically return responses in formats like JSON or XML, they can be easily consumed by various client-side technologies, including web and mobile applications. This adaptability contributes to their popularity, as developers can work with familiar tools and libraries to interact with the API seamlessly.

The other options highlight characteristics that do not align with the core benefits of REST APIs. The response framework of REST is designed to be simple rather than complex, making option one less applicable. While REST can handle standard transactions efficiently, it may not be the best choice for high-volume batch processing, which is often better suited for other methods like SOAP APIs or bulk data processing tools. Lastly, one of REST's strengths is its minimal setup and configuration requirements, contrasting with the suggestion that extensive setup is necessary.